Ergosterol health benefit and studies research
February 1 2017

Ergosterol is a biological precursor to Vitamin D2. Ergosterol is converted into viosterol by ultraviolet light, and is then changed into ergocalciferol, which is a form of vitamin D. Ergosterol is a component of fungal cell membranes, serving a similar function as cholesterol serves in animal cells.

Ergsoterol human study
As of 2017, we are not aware of ergosterol supplements in human studies.

Anti fungal drug
Itraconazole is an oral anti-fungal drug that works by inhibiting ergosterol synthesis via cytochrome P-450 dependent demethylation step.

Mol Plant Pathol. 2014. Ergosterol, an orphan fungal MAMP.

Ulcerative colitis remedy
The inhibitory effect of ergosterol, a bioactive constituent of a traditional Japanese herbal medicine saireito on the activity of mucosal-type mast cells.
Biol Pharm Bull. 2010; Kageyama-Yahara N, Yamamoto T, Kadowaki M. Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Mucosal inflammation in ulcerative colitis is presumed to be regulated primarily by type 2 T helper cell immune responses and mucosal mast cells in the colon are thought to play an important role in the pathogenesis of the mucosal inflammation. Saireito, a Japanese herbal medicine of standardized quality, originating from traditional Chinese medicine (Kampo medicine), is composed of two different Kampo medicines (shosaikoto and goreisan) and is often used for ulcerative colitis in Japan. In this study, we examined the direct effects of these Kampo medicines and their constituents on the antigen-induced degranulation of mucosal-type mast cells. Mucosal-type murine bone marrow-derived mast cells (mBMMCs) were pretreated by these drugs for 24 h. Goreisan showed inhibitory effects on degranulation of mBMMCs in a dose-dependent manner. Among the five constituent medicinal herbs of goreisan, Poria and Polyporus had the inhibitory effects on mBMMCs. Ergosterol, a principal and common component of Poria and Polyporus, also suppressed the degranulation of mBMMCs. Our results provide a molecular basis to explain a portion of the beneficial therapeutic properties of saireito on ulcerative colitis.

Ergosterol and wine fermentation
In wine fermentation, yeast is exposed to concentrated ethanol solutions. Ergosterol helps preserve the structural integrity of yeast membranes in stressful environmental conditions.

5htp and ergostserol herbal extract have not been studied in combination.